Endocrine Abstracts

Introduction: Epidemiological and In vivo experimental studies reveal reprotoxic effects of endocrine disruptors (phthalates (DBP, DEHP) and bisphenol A (BPA)). An inverse association was found between the concentration of these endocrine disruptors and the concentration of INSL3. INSL3, a relaxine peptide, is involved in reproductive function, via its cognate receptor, RXFP2. The aim of this study was to characterize the involvement of RXFP2 in the effects o...

Introduction: The relaxin family peptide receptor 2 (RXFP2) is the receptor for Insulin-like peptide-3 (INSL3). The INSL3/RXFP2 signaling is necessary in the first stage of testis descent. Besides, it is proposed that RXFP2 has a role in bone metabolism or in development of cancers (thyroid, prostate). RXFP2 is a rhodopsin-like G protein-coupled receptors (GPCR). Recently, it has been demonstrated that Drosophila RXFP2 had constitutive activity, i.e., a ligand-independent sign...

Introduction: Pituitary adenomas, second most common brain tumors, are mostly well controlled after surgery. However, some pituitary tumors present an aggressive evolution and are resistant to standard management. Immunotherapy with inhibitors of T-cell checkpoints have shown durable efficacy in a variety of malignancies. Moreover, immunotherapy has been associated with treatment-related hypophysitis, suggesting that pituitary could be a target of these treatments. Recently, i...

IntroductionProgressive and radioiodine-refractory thyroid cancer has poor outcomes and limited therapeutic options (i.e tyrosine kinase inhibitors) due to the transient efficacy of treatment and toxic effects. Therefore, combinatorial treatment with new therapeutic approaches are needed. Many studies link G Protein-Coupled Receptors (GPCRs) to cancer. The aim of this study is to present the first specific atlas of GPCRs expression in progressive and ref...

Aims: To assess the relationship between sleep quality and fear of hypoglycemia, glycemic variability and other diabetes-related outcomes in type 1 diabetes.Methods: Our data were provided by the VARDIA Study, a multicentric observational cross-sectional study conducted between June and December 2015. Sleep characteristics were assessed by Pittsburgh Sleep Quality Index (PQ1I). Fear of hypoglycemia was measured with the Hypoglycemia Fear Survey version I...